Consuming Glutathione in Foods and Supplements
Updated on April 3, 2020
100 Commentson Consuming Glutathione in Foods and Supplements
Glutathione is amazing.
글루타티온은 놀랍습니다.
Ever the underdog, few people have heard of this molecule, yet it supports nearly every aspect of our health.
약자였던 이 분자에 대해 들어본 사람은 거의 없지만 우리 건강의 거의 모든 측면을 지원합니다.
Consider these incredible properties:
By acting as an antioxidant, it prevents wear and tear on your tissues, helping you stay youthful, age gracefully, and remain free of chronic diseases.
다음과 같은 놀라운 속성을 고려하십시오:
항산화제 역할을 하여 조직의 마모를 방지하고, 젊음을 유지하고, 우아하게 노화하며, 만성질환에서 벗어날 수 있도록 도와줍니다.
매일 해독을 지원함으로써 주스, 허브 클렌징 또는 해독 목욕이 할 수 있는 것보다 훨씬 더 많은 것을 독소없이 유지합니다.
By supporting every-day detoxification, it does far more to keep you toxin-free than any juice fast, herbal cleanse, or detox bath could ever do.
세포가 성장하고 증식하며 스스로 회복되도록 도와줌으로써 어린이 성장을 돕고, 부상 후 치유를 돕고, 운동에 대한 반응에 적합하도록 도와줍니다.
By helping cells grow, multiply, and repair themselves, it supports growth in children, helps you heal after injury, and helps you get fit in response to exercise.
폐에서 점액을 유지하여 울혈을 예방하고 기도를 열어 천식을 예방합니다.
In the lungs, it keeps mucus fluid, preventing congestion, and it opens up the airways, preventing asthma.
우리는 세포 깊숙한 곳에서 매일 우리 자신의 글루타티온을 만들지만 식품으로도 섭취하며 보충제로도 사용할 수 있습니다.
이 자료는 글루타티온이 풍부한 식품을 섭취하고 올바른 글루타티온 보충제를 구입하는 방법에 대한 안내입니다.
그것은 285개 식품에서 검색가능한 글루타티온 데이터베이스로 끝납니다.
Although deep inside our cells we make our own glutathione every day, we also consume it in foods and it is available in supplements. This resource is a guide to consuming glutathione-rich foods and buying the right glutathione supplements. It ends with a searchable database of glutathione in 285 foods.
Can We Really Absorb Glutathione?
우리는 정말로 글루타티온을 흡수할 수 있습니까?
어떤 사람들은 글루타티온이 흡수되기 전에 소화관에서 분해되거나 산화되어 음식으로 먹거나 보충제로 사용하는 것이 쓸모가 없다고 지적할 수 있습니다.
Some people may point out that glutathione can be broken down or oxidized in the digestive tract before absorption, making it useless to eat it in foods or use it as a supplement.
글루타티온은 실제로 흡수되기 전에 분해되고 산화될 수 있지만 그대로 흡수될 수도 있습니다.
과학자들은 경구 용 글루타티온이 실험실 동물에서 그대로 흡수되고 글루타티온이 인간의 장 세포를 그대로 통과한다는 사실을 보여주었습니다.
그들은 관련된 운반체 중 일부를 확인했으며 경구 글루타티온이 동물과 인간 모두에서 글루타티온 상태를 증가 시킨다는 것을 보여주었습니다.
Although glutathione can indeed be broken down and oxidized before absorption, it can also be absorbed intact. Scientists have shown that oral glutathione is absorbed intact in laboratory animals, and that glutathione crosses human intestinal cells intact. They have identified some of the transporters involved, and have shown that oral glutathione increases glutathione status in both animals and humans.
Do Glutathione Supplements Need to Be Sublingual or Liposomal?
글루타티온 보충제는 설하 또는 리포솜이어야 합니까?
불행히도 우리는 더 간단하고 저렴한 "일반적" 글루타티온 보충제가 더 멋지고 더 비싼 설하 및 리포솜 보충제와 어떻게 비교되는지 거의 알지 못합니다.
한 연구는 설하 글루타티온이 3주 동안 일반 글루타티온보다 글루타티온 상태를 더 좋게 개선할 가능성을 암시하지만 추가 비용을 지불할 가치가 있습니까?
Unfortunately, we know very little about how the simpler, less expensive “regular” glutathione supplements compare to the fancier, more expensive sublingual and liposomal supplements. One study hinted at the possibility that sublingual glutathione improves glutathione status better than regular glutathione over the course of three weeks, but is it worth the extra cost?
Let's take the most generous interpretation of this study found in the marketing materials of Terry Naturally Clinical Glutathione, which claim 230% greater efficacy. This supplement costs $2.93 per gram of glutathione. By contrast, Jarrow Formulas Reduced Glutathione costs 60 cents per gram. Even if the sublingual form really were 230% better than the regular form, it's 488% more expensive. So, simple math shows that it's not worth it.
230% 더 높은 효능을 주장하는 Terry Naturally Clinical Glutathione의 마케팅 자료에서 발견된 이 연구에 대한 가장 관대한 해석을 취해 보겠습니다.
이 보충제는 글루타티온 1g 당 $ 2.93입니다.
대조적으로, Jarrow Formulas Reduced Glutathione은 그램당 60센트입니다.
설하 형태가 일반 형태보다 230% 더 우수하더라도 488% 더 비쌉니다.
따라서 간단한 수학은 그만한 가치가 없음을 보여줍니다.
연구를 비판적으로 살펴보면 설하 글루타티온은 훨씬 덜 인상적입니다.
자세한 분석은 아래 기술 노트를 참조하십시오.
If we take a critical look at the study, sublingual glutathione looks even less impressive. See the technical notes below for a more detailed analysis.
Liposomal glutathione has the advantage of being packaged into liposomes. Liposomes are small droplets enclosed by membranes that are very similar to our own cellular membranes. These membranes shield their contents from digestion and allow them to be taken up by cells as entire droplets.
리포솜 글루타티온은 리포솜으로 포장된다는 장점이 있습니다.
리포솜은 우리 자신의 세포막과 매우 유사한 막으로 둘러싸인 작은 방울입니다.
이 막은 내용물을 소화로부터 보호하고 세포가 전체 방울로 흡수할 수 있도록 합니다.
리포솜 글루타티온의 경우는 분리된 세포를 사용한 실험에 달려 있습니다.
The case for liposomal glutathione rests on experiments using isolated cells.
For example, liposomal glutathione is 100 times more effective at delivering glutathione to astrocytes, a particular type of brain cell.
예를 들어, 리포솜 글루타티온은 특정 유형의 뇌 세포인 성상세포에 글루타티온을 전달하는 데 100배 더 효과적입니다.
그러나 이들은 실험실에서 분리된 세포입니다.
But these are isolated cells in a laboratory.
When you consume liposomal glutathione as a supplement, do the liposomes all head straight to your astrocytes to be absorbed in tact?
Beats me.
리포솜 글루타티온을 보충제로 섭취하면 리포솜이 모두 성상세포로 곧바로 이동하여 재치있게 흡수됩니까?
나를 이깁니다.
안타깝게도 리포솜 글루타티온이 일반 글루타티온에 비해 우월하다는 것을 명확하게 기록한 인간 실험은 없으며 비용편익분석을 수행할 방법도 없습니다.
There are, unfortunately, no human trials clearly documenting the superiority of liposomal glutathione to regular glutathione, and there is no way to perform a cost-benefit analysis.
Still, some people may benefit from liposomal glutathione for the following reason.
그러나 일부 사람들은 다음과 같은 이유로 리포솜 글루타티온의 이점을 누릴 수 있습니다.
글루타티온은 신장, 심장, 폐, 뇌, 소장 및 피부에서 그대로 흡수되는 것으로 보입니다.
Glutathione appears to be taken up intact by the kidney, heart, lung, brain, small intestine, and skin.
그럼에도 불구하고 특정 세포 유형은 글루타티온을 그대로 흡수하는 능력이 없거나 많은 세포 유형이 스트레스 조건에 노출되었을 때 필요한만큼 흡수하지 못할 수 있습니다.
Nevertheless, it is possible that certain cell types lack the ability to take up glutathione intact, or that many cell types are not able to take up as much as they would need when exposed to stressful conditions.
In healthy people, these cells will simply make their own glutathione.
건강한 사람의 경우, 이 세포는 단순히 자신의 글루타티온을 만듭니다.
그러나 당뇨병, 인슐린 저항성, 감염 또는 만성염증이 있는 사람들은 글루타티온을 필요한만큼 많이 만들 수 없습니다.
People with diabetes, insulin resistance, infection, or chronic inflammation, however, are not able to make as much glutathione as they should.
Although poorly studied, liposomal glutathione may be preferable to regular glutathione for you if you suffer from any of these conditions.
잘 연구되지는 않았지만 이러한 상태 중 하나를 겪고 있다면 리포솜 글루타티온이 일반 글루타티온보다 선호될 수 있습니다.
또한 탄수화물 제한은 글루타티온 합성을 낮추므로 저탄수화물 식단을 섭취하는 동안 글루타티온 상태가 좋지 않은 경우 리포솜 글루타티온이 도움이 될 수 있습니다.
Additionally, carbohydrate restriction lowers glutathione synthesis, so liposomal glutathione may be helpful for you if you have poor glutathione status while consuming a low-carbohydrate diet.
Why Not Just Use N-Acetyl-Cysteine?
N-Acetyl-Cysteine을 사용하지 않는 이유는 무엇입니까?
글루타티온은 글루타메이트, 시스테인, 글리신의 3가지 아미노산으로 만들어집니다.
Glutathione is made from three amino acids: glutamate, cysteine, and glycine.
In an average healthy person, the limiting amino acid for its production is cysteine.
평균적으로 건강한 사람의 경우 생산을 위한 제한 아미노산은 시스테인입니다.
시스테인 자체는 매우 쉽게 분해되며 N-아세틸-시스테인 (NAC)은 이러한 분해를 방지하는 방식으로 시스테인을 제공합니다.
Cysteine itself degrades very easily, and N-acetyl-cysteine (NAC) provides cysteine in a way that prevents this degradation.
While NAC is likely to be effective at supporting glutathione status in many people, glycine may be limiting in other people, and NAC doesn't provide any glycine.
NAC는 많은 사람들의 글루타티온 상태를 지원하는 데 효과적일 수 있지만 글리신은 다른 사람들에게 제한적일 수 있으며 NAC는 글리신을 제공하지 않습니다.
또한, 위의 단락에 나열된 글루타티온 합성을 손상시키는 상태를 가진 사람들은 NAC를 사용하여 자신의 글루타티온을 만드는데 더 어려움을 겪을 것입니다.
Further, people with any of the conditions that impair glutathione synthesis, listed in the paragraph above, will have a more difficult time using NAC to make their own glutathione.
글루타티온 보충제는 2가지 문제를 모두 해결합니다.
Glutathione supplements get around both problems.
What Is the Best Dose of Glutathione?
Over the course of six months, both 250 mg and 1000 mg of oral glutathione have been shown to increase glutathione status in humans. The higher dose may be more effective than the lower dose, but we do not have sufficient data to make a rigorous comparison. See the technical notes below for a more detailed analysis.
As a prophylactic I believe a dose of 500 mg/d is likely to improve glutathione status when taken regularly over the course of several months.
How Do I know If I Should Take Glutathione?
Personally, I keep a bottle of Jarrow glutathione in my cabinet at all times, but I don't take it every day. If I get sick or am around sick people, I will take up to a gram per meal to support my immune system. If I develop any isolated respiratory symptoms such as wheezing, they tend to disappear rapidly if I take a gram of glutathione.
Although there are no clinical trials supporting these uses, 1 gram per day of glutathione for six months has produced no known adverse effects. Therefore, if 60 cents worth of glutathione might wipe out wheezing, why not try it? I believe this is a harmless form of first aid for non-emergency conditions.
There are two ways to determine whether you should use glutathione on a daily basis. First, if you know you have poor glutathione status. To determine your glutathione status, use the recommendations in Why You Should Manage Your Glutathione Status and How to Do It. Second, if you get sick often, feel you are aging too rapidly, or have a chronic disease.
While it is better to test than guess, testing can be expensive and glutathione supplementation appears harmless, so I think it is acceptable to self-experiment with supplements on the basis of symptoms alone, providing you do not use it as a substitute for professional medical treatment.
If any of these apply, I recommend trying one or two capsules of Jarrow glutathione per day. If these do not seem to give the desired result, try 500 mg of liposomal glutathione per day. If you find one to be better than other, please let me know in the comments!
For every-day general health, I recommend obtaining glutathione from foods rather than supplements.
Getting Glutathione From Foods
The food richest in glutathione are meats and vegetables. Fruits tend to occupy the middle tier, and most other foods are low in the glutathione. Processing such as canning and juicing degrades a large portion of the glutathione within a food.
Nevertheless, there is a lot of variation within categories, and I recommend searching our database for the foods you like to eat for a better view of what you are likely eating.
The database includes the following terms:
Reduced glutathione. This is the fully functional form of glutathione you would get from a supplement.
Total glutathione. This includes reduced glutathione and oxidized glutathione. Our cells regularly recycle oxidized glutathione back to its reduced form, so we can probably utilize the oxidized glutathione in foods.
Glutathione-reactive substances. These are substances that can irreversibly degrade glutathione. They may diminish the availability of glutathione from foods, and eating foods that are rich in glutathione-reactive substances and poor in glutathione could even rob us of the glutathione we have made ourselves.
Net glutathione. This is the total glutathione minus the glutathione-reactive substances.
Since we have not extensively studied the effect of consuming food glutathione on human health, it isn't 100% clear which term is best to use. The database sorts by reduced glutathione by default for two reasons: 1) this is the form found in supplements, so it is useful to compare what you would get from food versus supplements, 2) it has been measured in many more foods than net glutathione or glutathione-reactive substances has. Nevertheless, you can pick which term you want to sort by, and when you click on “view more details” for any given food, it will give you the complete information.
As an example of foods rich in reduced glutathione, consider the following:
Meat: one serving each of pork loin, chicken liver, and steak. 46.2 mg
Veggies: one serving each of asparagus, broccoli, and potatoes 46.3 mg
Fruit: one serving each of avocado, zucchini squash, and tomatoes 36.5 mg
You could eat all of these in a day, obtaining 130 mg of glutathione, and have room left over for plenty of other foods.
It is important to note that a food can be rich in glutathione and still bad for you. French fries, for example, are relatively rich in glutathione, but the high heat and fryer oil makes them a terrible food. A good diet is about more than glutathione. Still, glutathione is great! So check out the database to learn more about the glutathione you're consuming in your current diet.
Have any thoughts or experiences to share? Leave a comment! Love the post? Share it and show it love!
The Glutathione Database
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If you are human, leave this field blank. FOOD CATEGORY All Foods Beverage, Alcoholic Beverage, Nonalcoholic Breads, Grains, Legumes, and Nuts Dairy Foods and Eggs Fast Foods and Processed Foods Fats and Oils Fruits and Vegetables, Fruit Juices, and Fruit Drinks Meats and Fish Mixed Dishes Seasonings, Spices, Dressings SPECIFIC GLUTATHIONE VALUES Total Glutathione Reduced Glutathione (GSH) Glutathione-Reactive Substances Net Glutathione
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Other Searchable Nutrient Databases
If you found this database useful, try searching the vitamin K2 database, part of The Ultimate Vitamin K2 Resource.
Technical Notes About Glutathione Supplements
Comparing Sublingual Glutathione to Regular Glutathione
This was a randomized crossover study comparing N-acetyl-cysteine, reduced glutathione, and sublingual glutathione. Everyone underwent all three trials, and each trial lasted three weeks. During each trial, the subjects came in for measurements at the beginning, middle, and end. The most rigorous way to analyze the data is to look compare the ending value for each trial rather than the change during the trial. This is a protection against regression to the mean.
Using this approach, reduced glutathione was 8% higher after the sublingual trial than after the regular trial. The ratio of reduced glutathione to oxidized glutathione was 27% higher. To reach a 230% difference, the marketing materials of the sublingual product take advantage of the fact that the ratio of reduced glutathione to oxidized glutathione increased from 47.55 to 56.97 in the sublingual group but decreased from 51.68 to 44.76 in the regular group and compare the changes. This is not statistically sound. The fact that the ratio started off higher in the regular group than in the sublingual group means that it had more room to randomly fall while the sublingual group had more room to randomly rise. The principle by which randomly high things tend to fall down to the average and randomly low things tend to rise up to the average is called “regression to the mean,” and I've explained it in detail here.
If the ratio was 27% higher after sublingual glutathione and sublingual glutathione is 488% more expensive, then sublingual glutathione is 384% overpriced.
Comparing 250 mg to 1000 mg Oral Glutathione
The study that compared 250 mg to 1000 mg of oral glutathione reported most of its data as change from baseline, which, as described in the note above, is vulnerable to regression to the mean. Although a visual examination of the data does make it appear as though 1000 mg creates a larger effect that takes less time to kick in than 250 mg, there were no statistically significant differences between groups. Even if there were statistically significant differences between groups, we would not be able to rule out regression to the mean as a cause, since the absolute values for most measurements were not reported.
100 COMMENTS
Dale Almond
Posted on July 17, 2020 at 4:08 pm
While I consistently read that oral or sublingual glutathione has no reported side effects, I’ve tried almost every one on the market and my stomach and gut cannot tolerate any of them. So if any of you are also hyper-sensitive, what I do is take NAC, plus powdered glycine and some glutamate. I read up on the proportions of these in glutathione and attempt to follow that. The glycine and glutamine dissolve in water with stirring so it’s easy to take and tastes fine. I don’t know if it’s as effective as the glutathione supplements, but I’m getting benefits from it. For what it’s worth.
Shelley
Posted on July 17, 2020 at 11:14 am
Grateful for this article! Here is some subjective data for you: The four adults in our house took PE liposomal glutathione at your recommendation (what I had). Three felt significantly better – more energy, clarity- and the fourth got terribly depressed. One that felt better has just been diagnosed with mold toxicity (where from, I don’t know yet) and the other 2 have bad candida (and maybe mold too, have not check). So, it makes sense that those 3 felt better with the glutathione. Thanks again!
Nancy
Posted on April 15, 2020 at 2:30 pm
Hi,
Lab tests showed low Glutathione levels so I supplemented with capsules. Alleviated symptoms of fatigue, but made me very hungry and gained lots of weight. Same experience reported from sister and nephew. Looked it up and one study of 10 people showed only 1 person having this reaction. What is the possible explanation? Btw, switching to Liposomal increased effectiveness and neutralized hunger.
CARL E DANIELSEN
Posted on January 15, 2020 at 12:35 am
Two studies found centenarians have high levels of glutathione, equal to 70 year olds.
Nik
Posted on December 30, 2019 at 10:56 pm
Thoughts and recommendations for glutathione injections? Thank you for the information already shared.
Stephan
Posted on November 27, 2019 at 9:50 am
Exactly the kind of write-up I was looking for. Thank you for the accurate comparisons.It sheds some light on so many misleading marketing information. I would really like to see such a comparison of IV, Liposomal, Reduced and s-acetyl forms of Glutathione and their effects in skin whitening. Millions of people are going crazy about it. Would love to see some proofs/studies/comparisons and your thoughts.
Lynne Wood
Posted on November 18, 2019 at 1:58 pm
I would like to re-submit my comment as I did not receive any reply?
Lynne Wood says
April 2, 2019 at 1:50 pm
Speaking of genetics — I have no GSTM1 gene on either chromosome, meaning my detox capability is severely compromised. I have taken liposomal glutathione (about 428 mg./tsp. on an empty stomach every day for at least 10 years), and can’t tell if it is helping or not. I don’t trust my compromised digestive system to handle a pill, and I don’t do well on NAC. I have no doubt that my “toxic barrel” is overflowing. Any guidance on this would be much appreciated.
Posted on November 18, 2019 at 12:25 am
i use sitria glutathine 250 once daily,its supposed to be liosomal.i feel great
no problems.its called healthy origins brand only 21.oo for 150 caps.
thank you jack
Posted on October 17, 2019 at 3:00 pm
hi chris
i follow much of your nutritional advice,but i found a brand of glutathione
named setria ,a well known doc reccomended it amazon 150 caps of 250 mg
is 22 bucks the 500 mg is 38.oo.the brand name is healthy origins.i wish a was
your friend . all the best jack
Posted on November 27, 2019 at 8:42 pm
hi chris you should check out this h origins
glu brand.im a fussy buyer,they are a pa
american mgf co.thanks jack
doc fun
Posted on November 28, 2019 at 12:55 pm
You keep pushing this brand and it is just reduced glutathione, nothing more. They label it n-(n-l-gamma-glutamyl-l-cysteinyl) glycine instead of just reduced glutathione. That label doesn’t make it better. You also could use the IUPAC name, if you think it makes it better:
(2S)-2-amino-5-oxo-5-[[(2R)-1-oxo-1-[(2-oxo-2-propan-2-yloxyethyl)amino]-3-sulfanylpropan-2-yl]amino]pentanoic acid
duke
Posted on September 4, 2019 at 12:09 pm
I was curious as to why a low carb diet reduces glutathione synthesis. I have not seen this elsewhere and thats probably a issue if one is keto. I didn’t see any info on that. Could you provide me with additional information? I would like to know if I should be supplementing if I am keto. Thanks
Will Chase
Posted on August 2, 2019 at 5:57 pm
2 links. 1st is a 48 page PDF by a Dr Ben Lynch re Glutathione interolerance pretty useful yet much way over my head. 2nd is by a nutritionist specializing in such as histamine intolerance, IBS etc.. This is about a special form of reduced Glutathione found on Amazon and if you are so impressed via article may provide a link to this so you benefit from us purchasing via your helpful article.
https://wanp.org/wp-content/uploads/2018/12/Lynch-B.-Glutathione-Histamine.pdf
https://alisonvickery.com.au/new-ingredient-glutathione-setria/
Mindy
Posted on June 4, 2019 at 10:58 am
My lyme/Bartonella doctor has me on researched nutritionals tri fortify liposomal glutathione. It’s very expensive at $90 a tube and approximately 48 servings. Do you think this one is better than the core brand? I guess it does have more servingsbut the core brand does seem to come in at less cost anyway. I was just curious what your thoughts are on comparing the two brands.
This brand recommends taking it on an empty stomach. Have you found this to be the case?
Julio
Posted on January 8, 2019 at 12:33 pm
What’s an optimal leve of glutathione in a blood test.Had my levels checked and it was 270 something can’t recall exactly. The lab doesn’t give a range for normal or optimal.
Chris Masterjohn, PhD
Posted on January 9, 2019 at 7:23 pm
See here: https://chrismasterjohnphd.com/2017/01/13/manage-glutathione-status/
Al
Posted on January 9, 2019 at 10:27 pm
See below. Good stuff
David Perez
Posted on November 5, 2019 at 8:14 pm
My brother is disabled with Cerebral Palsy. The little guy is fed through a tube so nutrition is a very big challenge. He gets respiratory congestion very frequently. Many tests have been done and nothing. Only cause might have been acid reflux but highly unlikely. I’ll be supplementing with some glutathione supplement. I’ll keep you posted.
Diane Murphy
Posted on December 29, 2018 at 9:19 pm
Hi, Thank you, great article!
Do you know if oral Acetyl Glutathione will protect DNA from CatScan radiation ?
If so how many MG daily would you recommend and for how many months?
And can you take glutathione indefinitely?
Chris Masterjohn, PhD
Posted on January 4, 2019 at 11:23 am
I don’t know the answer to this currently.
Dale Almond
Posted on December 14, 2018 at 12:50 pm
I have tried the liposomal glutathione gelcaps and two different liquid liposomal glutathiones. All of them destroy my stomach and/or esophagus. It’s not a pH thing – I brought the pH up to 7.0 with baking soda (suggested by one manufacturer) and my reaction was the same. I do have a number of serious, chronic conditions (as well as genes that prevent normal production of glutathione) that keep my stomach sensitive. Is there any reason to think that taking the Jarrow capsules you recommend would be different? I just discovered that a compounding pharmacy will make transdermal glutathione? Other than financially, do you see any downside to that?
Sarah Harding
Posted on December 15, 2018 at 9:06 pm
Since this first came out- I have been researching ways to change the expression of genes that normally prevent normal glutathione production. I’ve made an intriguing discovery and in the last 6 months, I’ve improved my health and also witnessed other clients improving their health as well. Many of us struggled with nutrient deficiencies that would normally be attributed to our methylation and other “genetic” variant issues. I highly recommend researching the production of glutathione vs. the supplementation of it.
Dale Almond
Posted on December 31, 2018 at 3:29 pm
Hello Sarah,
When you say you’ve made a discovery, do you mean supplementing with glutathione precursors? I’ve been taking n-acetyl cysteine for a long time, but am about to add glutamine and glycine, which are the other two components. I’m not sure about ratios – I can’t find any guidance on that. I also have to be careful with glutamine, because I have a lot of GAD1 snps, so too much causes a lot of pain and inflammation. If you’ve made a different discovery, I would humbly ask that you point me in the right direction, if possible. Thank you.
Kim
Posted on September 26, 2019 at 9:36 am
What was your discovery?
Chris Masterjohn, PhD
Posted on December 19, 2018 at 11:45 am
It’s possible it would be different because this could be a negative reaction to the liposomes.
Al
Posted on January 10, 2019 at 12:55 am
Dale. Send an email outside of post. Doctoroffun@me.com and I can get a new glutathione sent to you at no charge. In respect to Chris I do not want to do any commercial discussion on his great site.
Lynne Wood
Posted on April 2, 2019 at 1:50 pm
Speaking of genetics — I have no GSTM1 gene on either chromosome, meaning my detox capability is severely compromised. I have taken liposomal glutathione (about 428 mg./tsp. on an empty stomach every day for at least 10 years), and can’t tell if it is helping or not. I don’t trust my compromised digestive system to handle a pill, and I don’t do well on NAC. I have no doubt that my “toxic barrel” is overflowing. Any guidance on this would be much appreciated.
Tucker
Posted on December 9, 2018 at 7:45 pm
My friend has an abnormal digestive system. Can Liposomal Glutathione be taken rectally ?
Chris Masterjohn, PhD
Posted on December 12, 2018 at 9:00 pm
I don’t know.
Al
Posted on December 4, 2018 at 6:13 am
Jarrow product contains Magnesium Stearate that can inhibit absorption. Shop for a product without.
Shelley
Posted on November 13, 2018 at 3:07 am
Can you take liposomal glutathione and NAC simultaneously if severely depleted in glutathione? Will taking liposomal switch off the body’s ability to generate its own glutathione? Many thanks for your comprehensive and well researched articles.
Chris Masterjohn, PhD
Posted on November 14, 2018 at 6:35 pm
I wouldn’t bother with the NAC in that case. In theory taking any GSH should downregulate GSH production but a human study showed that 6 months of taking GSH did not suppress GSH synthesis in the people’s red blood cells.
Kathy
Posted on October 28, 2018 at 1:23 pm
I’ve been prescribed liquid Glutathione for injection.Can you take the liquid Glutathione, by mouth. Holding it your mouth for absorption for a few minutes then spitting it out? Shots get pretty pain full
Chris Masterjohn, PhD
Posted on November 7, 2018 at 6:51 pm
Ask the prescribing doctor.
Posted on October 6, 2018 at 2:18 pm
Thanks for the well researched and structured article.
Question – do you really notice that taking a gram of glutathione alleviates a “wheeze?” And when you say you “wheeze” is this from asthma or what? Please clarify.
Glutathione has been on our radar – but the conflicting information on its ability to actually make it into the cells and tissues is what has stopped us from adding it to our regimen. We’ve become tired of taking supps that do not deliver some sort of measurable difference.
Thanks
Chris Masterjohn, PhD
Posted on October 8, 2018 at 3:13 pm
I do, that’s why I said it. I can’t clarify if it’s “asthma” because I know when I wheeze but I don’t have a doctor on hand to diagnose it as asthma.
Sarah
Posted on August 15, 2018 at 1:57 am
What about NRF2 pathway activation and it’s purported ability to boost antioxidant production? Have you taken a look at that? It has my hive in a buzz. We are shredding up PubMed left and right but not finding anyone (like you) who has taken this for a spin.
Chris Masterjohn, PhD
Posted on September 18, 2018 at 10:12 pm
I believe I covered that here:
https://chrismasterjohnphd.com/2017/01/13/manage-glutathione-status/
Sarah Harding
Posted on December 15, 2018 at 9:03 pm
Ah yes you linked to one of the studies we have discussed. So why aren’t you more interested in activating that NRF2 pathway to increase the production of antioxidants?
Chris Masterjohn, PhD
Posted on December 18, 2018 at 8:03 pm
I have in fact discussed this in what I’ve written about glutathione. This article is very specifically about consuming glutathione in foods and supplements, which is precisely made clear in the title. See here: https://chrismasterjohnphd.com/2017/01/13/manage-glutathione-status/ and search the site for “glutathione.”
Leah
Posted on June 15, 2018 at 8:05 pm
Chris, thank you for all your work. I started taking 500mg of oral glutathione and after a couple days got very sick with nausea and fatigue. What could this be?? I have T1 diabetes, hypothyroidism and NDPH (new daily persistent headache). Could it be a detox reaction?
shane
Posted on May 23, 2018 at 11:26 pm
What about S Acetyl Glutathione? that appears to be cheaper and from what some folks are saying it is more absorb able than liposomal.
David
Posted on November 15, 2019 at 3:42 pm
No Reply for you!
Matthew
Posted on January 13, 2018 at 7:30 am
Hi Chris,
Personally, been a bit nervy for a while now about taking NAC or glutathione on a regular basis after I read studies about how thiol antioxidant supplement (as well as vitamin E, I believe) significantly suppress not just macro autophagy but basal as well. In turn, such supplements can work to negate AMPK-activation benefits related to such nutraceuticals, such as curcumin and berberine.
Many chronic health conditions are characterised by high oxidative stress but also it dysfunctional autophagy, resulting in suboptimal clearing of misfolded proteins. Does this mean that glutathione-related supplements should be taken every other day or so in order to achieve some sort of balance between autophagy and ROS scavenging??
Many thanks for you excellent blog and podcast.
Mainpal
Posted on November 11, 2017 at 3:00 am
Amazon
Bulk supplements
Glutathione reduceed powder
Posted on August 24, 2017 at 3:58 am
Interesting I was always dubious about consuming glutathione in oral form as i’d heard it was just be digested and not utilised so it’s good to know that’s not the case.
Jacob D
Posted on August 19, 2017 at 7:45 pm
I have a simple solution : purchase liposomal or free glutathione, mix your dose of choice with 1ml of MCT oil. Then, suck the glutathione/MCT into a pipette or syringe (syringe, NOT needle). Lube the tip of the pipette/syringe with vaseline/MCT, and administer it intrarectally.
Bioavailability should be high (almost as much as IV), the MCT should help it absorb, 1/3 of the glutathione will instantly hit the liver (portal vein), the rest will hit the rest of the body.
I might start doing this daily hahah, I feel as though it would be very helpful for health. It’s basically a suppository. I have had really good experiences with NAC, but glutathione seems to be much better. Never tried gluathione though so we’ll see.
I also think an intranasal liposomal glutathione would be extremely interesting. The nasal route would increase brain concentrations extremely extremely high, and the lipsomal aspect would make the penetration even higher. Bet it would be great for cognition.
The sky’s the limit.
Peter Mengos
Posted on August 6, 2017 at 11:38 pm
best glutathione guide!
Chris Masterjohn, PhD
Posted on August 13, 2017 at 8:42 pm
Thanks!
Gail
Posted on June 28, 2017 at 3:34 pm
Thanks for an interesting resource. However, I am confused by some of the items in the database. For example, spinach says it has Reduced Glutathione (GSH) 12.3 ± 23 — so the glutathione can be anything from -10.7 mg/100g to +35.3 mg/100g — how can it have a negative amount of glutathione? Is this a typo (in which case I saw several others), or is it due to some countering factor in spinach?
Also, are the values in the database for cooked or raw spinach?
Thanks!
Dr Meg Ann Lawson
Posted on June 9, 2017 at 8:09 am
Question? I was taught in my Masters program in clinical nutrition that oral glutathione gets destroyed in the gut from the gastric juices. That’s why sublinguinal or IV injection are the recommended method for pure glutathione. Or one could supplement with NAC and collagen , and low dose DHEA (5-10 mg to help it’s absorption). Nutriwest makes an affordable sublingual glutathione, too.
Rowan Katharine Miller
Posted on May 22, 2017 at 1:42 pm
I have been taking this liposomal glutathione for about a year, it tastes fine, and it has really boosted my immune health tremendously!
https://www.seekinghealth.com/optimal-liposomal-glutathione-30-servings
Alisha
Posted on December 23, 2017 at 9:26 am
Did u take it on an empty stomach or with food?
james boatner
Posted on May 18, 2017 at 4:07 pm
Thanks chris! Can glutathione be taken on an empty stomach, or will that cause less absorption or GI upset?
On a side note, Do you think 1.5 teaspoons a day of cod liver oil providing vitamins A/D/E and 1.5 grams total of DHA and EPA (in favor of DHA) is safe to use? My diet is otherwise low in PUFAs and I make sure I get in 4-6 egg yolks a day, and 2-4 oz chicken liver daily. I was using 2-3 grams total of EPA/DHA a day (in favor of EPA) for several years and my diet was deficient in Arachidonic acid which I found out through a fatty acid RBC analysis. I developed many GI problems (very gradually) over that time and after reading your article my unbalanced intake of the omegas and AA has led to it. I am trying to reverse that now.
Carrie
Posted on May 16, 2017 at 2:56 pm
Are there any cases where it would be contraindicated? My husband has a blood cancer called polycythemia vera and they have him on Pegasys interferon and hydroxyurea and I worry about what these meds might be depleting.
Allen
Posted on May 16, 2017 at 2:39 pm
Very informative, factual and well presented. Great work, Chris!
Theron James
Posted on May 10, 2017 at 7:18 pm
Any thoughts or feels about Bulletproof’s Glutathione Force compared to Core Med Science Optimized Liposomal Glutathione? They claim “proprietary compound of phosphatidylcholine, palmitic acid and oleic acid to encapsulate and deliver glutathione in its complete form to the small intestine”
Chris Masterjohn, PhD
Posted on May 10, 2017 at 10:03 pm
Well, if it’s proprietary, and there are no studies, it’s kind of hard to develop any thoughts.
Lisa
Posted on May 10, 2017 at 9:45 am
Great article, thank you!
How/why does carbohydrate restriction lower glutathione synthesis?
Chris Masterjohn, PhD
Posted on May 10, 2017 at 10:04 pm
Hi Lisa, I covered that in detail here: https://chrismasterjohnphd.com/2017/01/13/manage-glutathione-status/
Lisa
Posted on May 11, 2017 at 12:07 am
Cool thank you!
Chris Masterjohn, PhD
Posted on May 12, 2017 at 9:47 pm
You’re welcome Lisa!
ShaSha
Posted on May 8, 2017 at 8:40 pm
I would also like to know whether cooking destroys this nutrient in potatoes.
Chris Masterjohn, PhD
Posted on May 9, 2017 at 8:57 pm
Given that french fries have a similar amount, it would seem not too much.
Posted on May 8, 2017 at 8:27 pm
Chris, with the assumption that any and all decisions should be first discussed with a healthcare provider, what’s your risk assessment of various methods of direct glutathione supplementation during pregnancy or lactation?
If it avoids the mother having to take an antibiotics course to fix an infection (and resulting detrimental impact on fetus/nursing infant), it has done a really good deed. Thanks
Chris Masterjohn, PhD
Posted on May 9, 2017 at 8:58 pm
I’m not familiar with any research in this area. However, glutathione is found in food and at the doses discussed in this post I would be surprised if there were any pregnancy risks to it.
Posted on May 10, 2017 at 10:15 am
Thanks Chris. That is what I was assuming as well. Particularly when the supplements are only taken temporarily during times of duress (i.e. likely glutathione depletion).
Mr Beef
Posted on May 8, 2017 at 2:23 pm
I would also like to know if supplementing with glutathione may reduce your body’s own synthesis of it?
Chris Masterjohn, PhD
Posted on May 9, 2017 at 8:59 pm
Mr Beef, the six-month study found synthesis was unaffected in red blood cells, but they didn’t show the raw data and they didn’t measure it in other tissues. I assume that somewhere the synthesis will be reduced, because glutathione regulates its own synthesis through negative feedback. However, the effect on glutathione status is net positive, and it is normal to consume glutathione in foods.
Diego
Posted on May 8, 2017 at 1:34 pm
One thing I found lacking in the podcast is if cooking destroys glutathione on veggies. Potatoes are said to be pressure cooked to inactivate lectins; so Im wondering if high pressure cooking destroys glutathione on potatoes too.
Chris Masterjohn, PhD
Posted on May 9, 2017 at 9:00 pm
I think I mentioned spinach, didn’t I? If you compare the values you do see considerable loss in some foods. Some are more stable than others. Potatoes seem to be more stable, spinach less stable. Similarly, grapefruit seems to be extremely vulnerable to juicing, orange moderately so. For a better view, play with the database.
Diego
Posted on May 7, 2017 at 7:56 pm
Do you think rectal administration of reduced glutathione supplement would aid in absorption? I’ve read some at the skin-whitening crowd to use it that way.
Chris Masterjohn, PhD
Posted on May 9, 2017 at 9:03 pm
I have no idea, Diego, sorry.
CHRIS CUDLIP
Posted on May 7, 2017 at 5:48 pm
You completely left out Acetyl Glutathione,
which may be the best form of all.
Chris Masterjohn, PhD
Posted on May 9, 2017 at 9:03 pm
Please use bold, underline, and italics for “may be,” given that, to my knowledge, this has not been tested in humans.
Ross
Posted on May 7, 2017 at 3:59 pm
Hi Chris,
Quick question about glutathione supplements (but I guess could be relevant to some other supplements, too).
Will supplementation of exogenous glutathione down-regulate production of endogenous glutathione? I asked this question in relation to digestive enzymes once and was told that the body will down-regulate endogenous production.
Is this correct?
Many thanks,
Ross
Chris Masterjohn, PhD
Posted on May 9, 2017 at 9:04 pm
Ross, yes, but see my comment to Mr. Beef.
Posted on May 7, 2017 at 2:18 pm
Chris,
Great information! I have shared it. I am one of those that does NAC for glutathione support. My immune status (I have Hashimoto’s) is much improved since living a clean lifestyle and eating real foods. There is of course, supplements that I use to continue to deliver optimal health. I am a studier of supplements. What is your take on the magnesium stearate that is indeed also found in Jarrow’s brand? I’d like to switch over, but the magnesium stearate tends to create poor absorbability, as vilified by Suzy Cohen and several others. Thanks again for what you do.
Chris Masterjohn, PhD
Posted on May 9, 2017 at 9:05 pm
Hi Carol,
At the moment, I do not worry about Mg stearate because what I have seen of the vilification has not looked convincing, but I have not researched it exhaustively.
Posted on May 7, 2017 at 2:10 pm
Hi Chris,
WAPF chapter leader here
I am nebulizing glutathione, using this brand:
It is the only brand that specifically mentions being suitable for nebulizing. Do you think I could use a cheaper brand?
Also, would love to hear your thoughts on nebulizing!
Cheers,
Sally
Chris Masterjohn, PhD
Posted on May 9, 2017 at 9:06 pm
Hi Sally,
I get the point of nebulizing, but I haven’t researched it enough to give specific brand recommendations.
Kira Miftari
Posted on May 7, 2017 at 2:07 pm
Thank you, amazingly thorough review, a per usual! ;-)) I am also wandering if you looked at S-acetyl glutathione and do you think its as effective or more effective than the liposomal form? And does it seem more expensive than Liposomal? TIA!
Chris Masterjohn, PhD
Posted on May 9, 2017 at 9:07 pm
Kira, to my knowledge it hasn’t been studied in humans. You’re welcome!
Ryan
Posted on May 7, 2017 at 1:58 pm
Great article! Do you have any recommendations for relatively low-cost lab tests that might help to quantify GSH status / needs? (I see a “Glutathione Blood Test” offered by LEF for $112.)
I’ve been curious what an ideal approach might look like for cycling phytochemicals, GSH-cofactors, and GSH itself around a low-carb high-fat diet. I see benefits for all of these strategies, but it doesn’t seem ideal to do them all together daily.
Chris Masterjohn, PhD
Posted on May 9, 2017 at 9:08 pm
See here: https://chrismasterjohnphd.com/2017/01/13/manage-glutathione-status/#lab
Lilian Holm
Posted on May 6, 2017 at 1:22 pm
Chris,
Thank you for yet another invaluable article le on glutathione. To your knowledge, does supplemental glutathione affect the body’s endogenous production of the same?
Thanks!
Lilian
Chris Masterjohn, PhD
Posted on May 9, 2017 at 9:10 pm
Lilian, please see my comment to Mr. Beef.
Posted on May 9, 2017 at 9:47 pm
Chris,
I really appreciate the clarification, thank you!
Lilian
Chris Masterjohn, PhD
Posted on May 10, 2017 at 10:09 pm
You’re welcome, Lilian.
framistat
Posted on May 6, 2017 at 8:23 am
Actually Lucky Vitamin has the Jarrow glutathione for quite a bit less…
Kai
Posted on May 7, 2017 at 3:04 am
I just checked it… it says $42.99 for the 120 @ Lucky. Amazon has it right now for $36 PLUS they have a 15% off coupon the first time you buy it. Bulk Supplements on Amazon has it cheaper if you want to buy a crazy large amount, but then it’s not in pills either (and Jarrow is a great company).
Chris Masterjohn, PhD
Posted on May 9, 2017 at 9:09 pm
Thanks Kai.
Chris Masterjohn, PhD
Posted on May 9, 2017 at 9:10 pm
I’d never heard of them, but Kai found it is less expensive on Amazon. Thanks for pointing out Lucky though.
Scott
Posted on May 6, 2017 at 1:20 am
Great information…thank you Chris! What are your thoughts regarding S-acetyl glutathione?
Barry
Posted on May 7, 2017 at 2:02 pm
So taking an NAC supplement with a glass of water+hydrolyzed Collagen would do the trick, yes?
You get the glutathione/glycine benefit plus of all the other amino acids and collagen!
Chris Masterjohn, PhD
Posted on May 9, 2017 at 9:02 pm
If you have good synthesis of glutathione, yes; if not, no.
Brennan
Posted on May 8, 2017 at 10:02 am
I would really like to know this as well. I haven’t seen Chris mention it but there is research that shows it is effective.
Brennan
Posted on May 8, 2017 at 10:14 am
I started looking and I did find a facebook post by Chris Kresser where he posted some research that liposomal is potentially more effective than s-acetyl. I don’t know if the answer is clear but it seems both are more effective than other forms of oral GSH supplementation.
https://www.facebook.com/chriskresserlac/posts/561353040583630
Chris Masterjohn, PhD
Posted on May 9, 2017 at 9:01 pm
Interesting, though that’s in neuronal cells and like I said there’s nothing in humans.
Chris Masterjohn, PhD
Posted on May 9, 2017 at 9:11 pm
Scott, to my knowledge it hasn’t been tested in humans.
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